N-Benzoyl-N'-3-indolyl-N'alkyl-1,3-diaminopropanes

Details N-Benzoyl-N'-3-indolyl-N'alkyl-1,3-diaminopropanes N-Benzoyl-N'-3-indolyl-N'alkyl-1,3-diaminopropanes

1980-01-11

1982-09-21

Springer, David B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032613H, 26032612R, 26032615, 546 65, 546193, 546201, 424274, 424275, 424267, 424263, C07D20912, A61K 3140

Patent

active

043506348

ABSTRACT:
The invention provides indole compounds useful for the treatment of hypertension, processes for the preparation of said compounds and pharmaceutical compositions containing these compounds.
The compounds of the invention have the formula ##STR1## wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R.sub.1 is H or alkyl, or A together with NR.sub.1 is 4-piperidyl, R.sub.2 is hydrogen or alkyl, R.sub.3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R.sub.4 is hydrogen, chlorine, bromine or alkyl, R.sub.5 is hydrogen, alkyl, alkoxy or alkylthio, and X is --CO-- or --CS.

REFERENCES:
De Groot et al, J. Org. Chem., 31, p. 3954 (1966).
Archibald et al, J. Med. Chem., vol. 14, No. 11, p. 1054 (1971).

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