Procedures for preparing composite materials from collagen and g

Details Procedures for preparing composite materials from collagen and g Procedures for preparing composite materials from collagen and g

1981-07-29

1982-09-21

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

106155, 106157, 1283355, 128349R, 128DIG8, C07G 700, C08H 100, C08H 106

Patent

active

043506291

ABSTRACT:
This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the materials produced have extremely low levels of thrombogenicity. Such materials are well suited for in-dwelling catheters, blood vessel grafts, and other devices that are in continuous contact with blood for long periods of time.

REFERENCES:
patent: 3527225 (1970-09-01), Smith
patent: 4060081 (1977-11-01), Yannas et al.
patent: 4233360 (1980-11-01), Luck et al.
patent: 4280954 (1981-07-01), Yannas et al.

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