Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Details Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines

1977-06-08

1979-12-25

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424267, 544 92, 2602455, 2602433, 548262, C07D48704

Patent

active

041806689

ABSTRACT:
6-Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.3 -alkyl, R.sub.1 is hydrogen or halogen, and the two R.sub.2 groups are taken together with the nitrogen to which they are bonded to complete a nitrogen ring moiety selected from the group consisting of pyrrolidino, piperidino, morpholino and 3,6-dihydro-1(2H)-pyridyl, and the pharmacologically acceptable salts thereof, are central nervous system depressant drugs which are useful in effective dosages in domestic and zoo animals for their calming and tranquilizing uses during shipment and to reduce aggressive behavior. In man these compounds are potentially useful for controlling anxiety and schizophrenia and for their sedative, muscle relaxant and anti-convulsant activity.

REFERENCES:
patent: 3414563 (1968-12-01), Griot
patent: 3767660 (1973-10-01), Hester
Moffett, R., Letters on Heterocyclic Chemistry, 3, pp. 5-123-130 (1976).
Garattini, S. et al., Editors, The Benzodiazepines, Raven Press, New York, 1973, pp. 288-289.

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