Pyran analogs of 4,5,13,14-tetradehydro-PGI.sub.1 compounds

Details Pyran analogs of 4,5,13,14-tetradehydro-PGI.sub.1 compounds Pyran analogs of 4,5,13,14-tetradehydro-PGI.sub.1 compounds

1978-06-14

1979-12-25

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

542426, 424283, C07D31102

Patent

active

041805127

ABSTRACT:
The present invention relates to certain novel pyran analogs of 4,5,13,14-tetradehydro-PGI.sub.1 compounds wherein the C-5 to C-6 double bond of prostacyclin (PGI.sub.2) is isomerized to the C-4 to C-5 position, the heterocyclic ring of PGI.sub.2 is enlarged to 5 carbon atoms, and the C-13 to C-14 double bond is further unsaturated to a triple bond. These novel pyran analogs are useful as smooth muscle stimulators.

REFERENCES:
Johnson et al., Prostaglandins, 12, 915 (1976).

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