Ortho-substituted benzoylguanidines, process for their preparati

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514622, 514634, 564176, 564237, A61K 31165

Patent

active

060750545

ABSTRACT:
Benzoylguanidines of formula I ##STR1## with R(1) to R(4) as defined in the specification, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris.
They inhibit, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.

REFERENCES:
patent: 5747539 (1998-05-01), Dorsch et al.
patent: 5856574 (1999-01-01), Weichert et al.
English Language Abstract of EP 0 640 588 A1 (Derwent Abstract No. 95-092257).
English Language Abstract of EP 0 704 431 A2 (Derwent Abstract No. 96-130135).
English Language Abstract of EP 0 814 077 A1 (Derwent Abstract No. 98-044281).

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