DNA sequencing by mass spectrometry via exonuclease degradation

Details DNA sequencing by mass spectrometry via exonuclease degradation DNA sequencing by mass spectrometry via exonuclease degradation

1996-11-06

2000-06-13

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435196, 250282, C12Q 168, C12N 916

Patent

active

060748230

ABSTRACT:
The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally degraded in a stepwise manner via exonuclease digestion and the nucleotides, derivatives or truncated sequences detected by mass spectrometry.

REFERENCES:
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), Koster

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