Method and apparatus for increased electrospray ion production

Details Method and apparatus for increased electrospray ion production Method and apparatus for increased electrospray ion production

1997-10-07

2000-11-14

Anderson, Bruce C.

Radiant energy

Ionic separation or analysis

With sample supply means

250281, 250423R, H01J 4700, B01D 5944

Patent

active

061473456

ABSTRACT:
An improved electrospray ion production method and ion source designed to increase the current generated from the electrospray process. A method and device are disclosed that utilize controlled counter-ion impingement onto an electrospray cone-jet in order to increase the total current of the spray and impart additional energy into the surface of the cone-jet. Gas-phase counter-ions are generated external to the needle and attracted by the high field gradients into the surface of the electrospray cone-jet. The counterions impinging into the surface of the electrospray cone-jet will dissolve and participate directly or indirectly in an increased electron transfer rate at the needle electrode. This process results in increased total analyte ion transfer to the cone-jet surface, increased charge on droplets, and increased transport of analyte from the liquid into the gas phase. The method is useful for increasing the detection sensitivity of analytes in solution that are electrosprayed and analyzed with mass spectrometry.

REFERENCES:
patent: 5753910 (1998-05-01), Gourley et al.
patent: 5828062 (1998-10-01), Jarrell et al.
patent: 5873523 (1999-02-01), Gomez et al.
patent: 5945678 (1999-08-01), Yanagisawa

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