Production of 5-perfluoroalkyldihydrouracil derivatives

Details Production of 5-perfluoroalkyldihydrouracil derivatives Production of 5-perfluoroalkyldihydrouracil derivatives

1983-08-26

1986-04-08

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

562553, 562556, 562560, 564 31, 564 58, 564 60, C07D23922, C07C 5703, C07C12517, C07C15705

Patent

active

045814520

ABSTRACT:
A process for preparing a 5-perfluoroalkyl-dihydrouracil derivative of the general formula ##STR1## wherein R.sub.f represents a perfluoroalkyl group, each of R.sup.1 and R.sup.2 represents a hydrogen atom, or an alkyl, cycloalkyl, aryl, aralkyl or heterocyclic group, and Y is an oxygen or sulfur atom, which comprises (a) reacting a compound of the general formula ##STR2## wherein X represents a halogen atom or hydroxyl group, with a urea derivative of the general formula ##STR3## provided that when X is a hydroxyl group and at least one of R.sup.1 and R.sup.2 is a hydrogen atom, said reaction is carried out in the presence of a condensing agent, or (b) cyclizing a compound of the general formula ##STR4## and a novel intermediate compound of the above formula (IV).

REFERENCES:
patent: 2572568 (1951-10-01), Gluesenkamp
patent: 3201387 (1965-08-01), Heidelberger
Heidelberger et al., J. Med. Chem., vol. 7, No. 1, pp. 1-5, (1964).

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