System for delivering agent to environment of use over prolonged

Details System for delivering agent to environment of use over prolonged System for delivering agent to environment of use over prolonged

1976-12-15

1979-12-25

Padgett, Benjamin R.

Surgery

Truss

Pad

71 1, 71 65, 71 3, 71 64F, 128260, 424 19, A61K 3100, A61K 3156, A61K 4700, A61K 902, A61F 546, A61M 3100

Patent

active

041800648

ABSTRACT:
A device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic acid) having one ionizable carboxylic hydrogen for each 8 to 12 carbon atoms, which material erodes at a controlled and continuous rate over a prolonged period of time in response to the environment by a process of carboxylic hydrogen ionization, thereby releasing the dispersed agent at a controlled rate over a prolonged period of time.

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patent: 3986510 (1976-10-01), Higuchi et al.
patent: 4014987 (1977-03-01), Heller et al.
Lappas, L., et al., J. Pharm. Sci., vol. 56, pp. 1257-1261 (1967).
Heyd, A., et al., J. Pharm. Sci., vol. 58, No. 5, pp. 586-588 (1969).
Heyd, A., et al., J. Pharm. Sci., vol. 59, No. 7, pp. 947-949 (1970).

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