Substituted N-heteroaroylguanidines, a process for their prepara

Details Substituted N-heteroaroylguanidines, a process for their prepara Substituted N-heteroaroylguanidines, a process for their prepara

1995-04-07

1997-12-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 514313, 514314, 514307, 514309, 514310, 514326, 514397, 514422, 514444, 514445, 514448, 546153, 546155, 546157, 546159, 546162, 546163, 546167, 546141, 546142, 546143, 546144, 5462847, 546212, 546213, 5483151, 548527, 549 59, 549 60, 549 61, 549 62, 549 63, 549 64, 549 69, 549 70, A61K 3138, C07D33322

Patent

active

056985819

ABSTRACT:
The invention relates to heteroaroylguanidines of the formula I ##STR1## in which the substituents HA and R(1) to R(5) have the meanings given in the specification. These compounds exhibit very good antiarrhythmic properties and are outstandingly suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventative manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias.

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