Method for treating cyclic phosphate compound

Details Method for treating cyclic phosphate compound Method for treating cyclic phosphate compound

1998-10-06

2000-11-14

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544243, 435 89, 435 92, C07F 96512, C07F 96521, C12N 1531, C12N 916

Patent

active

061472115

ABSTRACT:
The invention relates to a compound of formula (I) ##STR1## Wherein: B is adenine, guanine or hypoxanthine
Z is hydrogen or a negative charge
R is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2, --CH.sub.2 CH.sub.2 X, in which
R.sup.1 is hydrogen or (C.sub.1 -.sub.6) alkyl
R.sup.2 is hydrogen or (C.sub.1 -.sub.6) alkyl
n is a number from 1 to 6
X is OH, F, NR.sup.3 R.sup.4
R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -.sub.6) alkyl
and to methods of enzymatically treating these compounds with biocatalysts having cyclic phosphodiesterase activity.

REFERENCES:
patent: 5382519 (1995-01-01), Dunlap et al.
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Altman et al., Chimia 50, No. 4, pp. 168-176 Apr. 1996.
Callahan et al., The Journal of Biological Chemistry, vol. 270, No. 29, pp. 17627-17632, Jul. 21, 1995.
Dunlap et al., Journal of General Microbiology, vol. 138, pp. 115-123 (1992).
Dunlap et al., Journal of Bacteriology, vol. 175, No. 15, pp. 4615-4624, Aug. 1993.
Martin, P., Separatum Helvetica Chimica Acta, vol. 78, pp. 486-504 (1995).
Martin, P., Separatum Helvetica Chimica Acta, vol. 79, pp. 1930-1938, (1996).
Mesmaeker et al., Accounts of Chemical Research, vol. 28, No. 9, pp. 366-374.
Tazawa et al., Biochemistry, vol. 11, No. 26, pp. 4931 to 4937 (1972).

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