Norepinephrine potentiated compositions and method of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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424 45, 514913, A61K 3135, A61K 904

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active

045813760

ABSTRACT:
Novel pharmaceutical compositions containing norepinephrine releasers such as alpha-adrenergic agonists, para-sympathomimetic agonists and carbonic anhydrase inhibitors in combination with a potentiating amount of norepinephrine are disclosed. Use of such compositions, exemplified by the combination of norepinephrine and epinephrine, in an ophthalmic solution for the treatment of glaucoma is also disclosed, as well as the use of the combination of norepinephrine and a norepinephrine releaser in the treatment of congestion in the upper respiratory tract.

REFERENCES:
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patent: 4275074 (1981-06-01), Langham
Chem. Abst. 78 52709(t) (1973)--Neufeld et al.
Glaucoma Update Krieglstein et al., pp. 19-26 (1979).
Chem. Abst. 88 99553(j) (1978)--Neeters.
Chem. Abst. 95 126085(m) (1981)--Innemee et al.
Chem. Abst. 98 191598(g) (1983)--Miichi et al.
Rote Liste, 1965, pp. 126, 127, 92, 93, 46, 47, Editio Cantor Aulendorf/Wortt., DE.
Merck Index (1960), pp. 57, 58, 395.sctn.608.
Douglas Gaasterland, et al., "Studies of Aqueous Humor Dynamics in Man III, Measurements in Young Normal Subjects Using Norepinephrine and Isoproterenol".
Duke-Elder, "Glaucoma in System of Ophtholomogy", vol. XI, Henry Kimpton, Lond, 1969.
Frank J. Macri, et al., "The Formation and Inhibition of Aqueous Humor Production", Arch Opthalmol, vol. 96, Sep. 1978.

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