3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles

Details 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles

1985-07-15

1986-04-08

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 546168, 546187, 514222, 546197, 546201, 514228, 548336, 548454, 514230, 548465, 548468, 514231, 548493, 548505, 514232, 2602456, 2602457, 514234, 514237, 514238, 514252, 514314, 514316, 514321, 514323, 514397, 514414, 544 582, 544 585, 544 586, 544 62, 544121, 544128, 544129, 544130, 544139, 544143, 544144, 544357, 544360, 544363, 544370, 544373, A61K 3140, A61K 31535, C07D20912, C07D41306

Patent

active

045813540

ABSTRACT:
3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalky- or haloalkyl-1H-indole with an amine.

REFERENCES:
patent: 2930798 (1960-03-01), Schmitt
patent: 3489770 (1970-01-01), Herbst
patent: 3946029 (1976-03-01), Deschamps
Croce, Chemical Abstracts, vol. 80 (1973) No. 95655f.

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