Use of 1,2-Bridged 1,4-dihydropyridines as medicaments

Details Use of 1,2-Bridged 1,4-dihydropyridines as medicaments Use of 1,2-Bridged 1,4-dihydropyridines as medicaments

1999-07-28

2000-11-14

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546112, A61K 3144, C07D22102

Patent

active

061470872

ABSTRACT:
The present invention relates to the new use of 1,2-bridged 1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 and a have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.

REFERENCES:
patent: 3867393 (1975-02-01), Meyer et al.
patent: 3935220 (1976-01-01), Meyer et al.
patent: 3951988 (1976-04-01), Meyer et al.
patent: 4053614 (1977-10-01), Meyer et al.
patent: 5225566 (1993-07-01), Butera et al.
Porsolt, R.D. et al., "Behavioral Despair in Rats: A New Model Sensitive to Antidepressant Treatments," Eur.J.Pharmacol. 1978, vol. 47, No. 4, pp. 379-391, abstract only.
Etcheberrigaray, E. et al., Annals of the New York Acad.Sci. Dec. 15, 1994, vol. 747, pp. 245-55, online search results relied upon.
Heinemann, U. et al.,Epilepsy Res. Suppl. 1992, vol. 9, pp. 107-14, online search results relied upon.
Lee, Y.S. et al, Cellular Signalling, Nov. 1993, 5(6), pp. 803-9, online search results relied upon.
Shang, H. et al., Pharm.Toxicol.Dec. 1994, vol. 75(6), pp. 327-36, online search results relied upon.
Furspan, P.B. et al., Hypertension, Feb. 1990, 15(suppl.2), pp. 197-1101.
H.Meyer, et al., Liebegs Ann.Chem., pp.1888-1894 (1977).
P.W.L. Tas, et al., Neuroscience Letters, vol. 94, pp.279-284 (1988).
Pflugers Archiv.European Journal Of Physiology, vol. 429, No. 2, Dec. 1994, pp.176-182.
J.C. Ellory, et al., Br.J. Pharmacol. vol. 111, pp.903-905 (1994).

Affiliated with

Also associated with

Rating

Use of 1,2-Bridged 1,4-dihydropyridines as medicaments does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of 1,2-Bridged 1,4-dihydropyridines as medicaments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of 1,2-Bridged 1,4-dihydropyridines as medicaments will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2065729