Methods for treating allergic disorders using optically pure (-)

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 31495

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active

056985584

ABSTRACT:
Methods are disclosed utilizing optically pure (-) cetirizine for the treatment of seasonal and perennial allergic rhinitis in humans while avoiding the concomitant liability of adverse effects associated with the racemic mixture of cetirizine. The optically pure (-) isomer is also useful for the treatment of allergic asthma.

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De Vos & Joseph et al., Int. Arch. Allergy Appl. Immunol., 88(1-2), 212-15, 1989. (from Chemical Abstracts).
Gong et al., 90:243620 Biosis, BA89:130573, 1990.
Testa et al. "Racemates Versus Enantiomers in Drug Development: Dogmatism or Pragmatism?"Chirality,2 129-133 (1990).
Schoeffter et al. "Competative and stereoselective histamine H.sub.1 antagonistic effect . . . " Eur. J. Parmacol., 136, 235-237 (1987).
Fricke et al. "Fortschiritte fur die Arzneimtteltherapie?"Neue Arzneimittel 1990/1991, 14-21 (1991).

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