Process for preparing intermediates of inhibitors of enkephalina

Details Process for preparing intermediates of inhibitors of enkephalina Process for preparing intermediates of inhibitors of enkephalina

1997-11-10

1999-02-16

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540519, 540521, C07D41704

Patent

active

058722513

ABSTRACT:
The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.

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Gary A. Flynn et al, J. Am. Chem. Soc., 1987, vol. 109, p. 7914.
Gary A. Flynn et al, Peptide Chemistry,1987,pp.631-636.
Flynn, et al., Tetrahedron Letters, vol. 31, No. 6, pp. 815-818 (1990).
Todd K. Jones et al., J. Org. Chem. 1991, vol. 56, pp. 763-769.
Joseph Foos, et al.,J. Org. Chem., vol. 44, No.14, 1979, pp. 2522 & 2529.
Roy, R.B. et al., Can. J. Biochem, vol. 52, 1973, p. 942.

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