Mercapto alkyl peptidyl compounds having MMP and TNF inhibitory

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548477, A61K 3140, C07D20948

Patent

active

058721460

ABSTRACT:
Described herein are compounds of formula (I): ##STR1## which have MMP and TNF inhibitory activity.

REFERENCES:
Ahlmquist, R.G. et al., (1992) "Development of Peptidomimetic Inhibitors of a Newly Isolated Altrail Peptide-Degrading Enzyme," In Peptides: Chemistry and Biology, as referred to in Proceedings of the American Peptide Symposium, Cambridge, Jun. 16-21, 1991, pp. 791-792.

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