High molecular and low molecular fractions of von Willebrand Fac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530383, 530412, A61K 3800

Patent

active

058720995

ABSTRACT:
The present invention relates to a method for separation of vWF into high molecular vWF and low molecular vWF which is characterized in that vWF is bound to an affinity support and is then eluted at different salt concentrations.

REFERENCES:
patent: 5110907 (1992-05-01), Kosow et al.
patent: 5149787 (1992-09-01), Kunicki et al.
patent: 5198423 (1993-03-01), Taguchi et al.
patent: 5200510 (1993-04-01), Kumar et al.
patent: 5408039 (1995-04-01), Burnouf-Radosevich et al.
Burnouf-Radosevich et al., Vox Sang 62: 1-11 (1992).
Andrews et al., Biochemistry 28: 8326-8336 (1989).
Titani et al., Biochemistry 25: 3171-3184 (1986).
Mancuso et al., J. Biological Chemistry 264(33): 19514-19527 (1989).
Thrombosis and Haemostatsis/Abstracts 73(6): 1160, Abstract 993 (1995).
Wagner et al., "Inhibition of Disulfide of von Willerbrand Protein by Monensin Results in Small, Functionally Defective Multimers", J. Cell Biol., vol. 101, pp. 112-120, Jul. 1985.
Senogles et al., "von Willerbrand Factor A protein which binds at the cell Surface Interface between Platelets", J. Biol. Chem., vol. 258, No. 20, pp. 12327-12333, Oct. 1983.
Aihara et al., "Two Affinity Immunoelectrophoretic Methods for studying Collagen Interaction with von Willerbrand Factor Antigen", Tohoku J. exp. Med. 1987, vol. 153, pp. 169-177, Aug. 1987.
Baillod et al., "Multimeric Analysis of von Willerbrand Factory by Vertical Sodium Dodecyl Sulphate Agarose Gel Electrophoresis, Vacuum Blotting Technology and Sensitive Visualization by alkaline Phosphatase Anti-Alkaline Phosphatase Complex", Throm. Res. vol. 66, pp. 745-755, 1992.
Putney, AIDS Vaccine and Research and Clinical Trials pp. 219-239, 1990.
Bradford, "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding", Anal. Biochem., vol. 72, pp. 248-254, 1976.
Falkner et al., "High Level Expression of Active Human Prothrombin in a Vaccina Virus Expression System", Throm., vol. 68, No. 2, pp. 119-124, 1992.
Barrett et al., "Large-Scale Production and Purification of a Vaccinia Recombinant-Derived HIV-1 gp160 and Analysis of Its Immunogenicity", Aids Res. and Human Retroviruses, vol. 5, No. 2, 1989.
Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature vol. 227, pp. 680-685, Aug. 15, 1970.
Furlan et al., "Triplet structure of von Willerbrand factor reflects proteolytic degradation of high molecular weight multimers", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 7503-7507, Aug. 1993.
Mannheim, Translation of relevant part of Witt Biochemistry of Blood Coagulation and Fibrinolysis, pp. 14-16, 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

High molecular and low molecular fractions of von Willebrand Fac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High molecular and low molecular fractions of von Willebrand Fac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High molecular and low molecular fractions of von Willebrand Fac will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2062616

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.