Inhibitors for the adhesion of lymphocytes to glandular cells

Details Inhibitors for the adhesion of lymphocytes to glandular cells Inhibitors for the adhesion of lymphocytes to glandular cells

1997-10-08

2000-11-14

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241521, 4241581, 53038822, 53038823, 5303887, A61K 39395, C07K 1628

Patent

active

061466301

ABSTRACT:
The present invention provides adhesion inhibitors for suppressing the adherence between E-cadherin of glandular cells and integrin of lymphocytes. Sjogren's syndrome comprises disorders wherein secretory glands such as lacrimal gland are destroyed by autoimmunity, and the adherence of CD8.sup.+ T cells to the surface of acinar cells is observed by the immunohistological analysis of lacrimal gland from patients. Integrin on the surface of T cells and E-cadherin on the surface of acinar cells play a major role in the mechanism of adhesion between these cells, while the adherence of T cells to acinar cells is reduced using anti-E-cadherin and anti-integrin antibodies. Sjogren's syndrome, such as autoimmune adenitis, can be treated using these antibodies.

REFERENCES:
patent: 5610281 (1997-03-01), Brenner et al.
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Hayashi et al. Clin Exp. Immunol. 102: 360, 1995.
Saito et al. J. of Clin. Lab Analysis 7: 180 1993.
Fox et al. In Textbook of Rheumatology 1993 Ed By Kelley et al. W. B. Saunders Co pp. 931-942.
Russell et al. Eur. J. Immunol. 24: 2832, 1994.
Caul: et al. Annals of Rheumatic Disease 54: 209, 1995.
K. L. Cepek, et al., "Integrin .alpha..sup.E .beta.7 Mediates Adhesion of T Lymphocytes to Epithelial Cells", The Journal of Immunology, vol. 150, 3459-3470, No. 8, Apr. 15, 1993.
K. L. Cepek, et al., "Adhesion between eithellal cells and T lymphhocytes mediated by E-cadherin and the .alpha..sup.E .beta..sub.7 Integrin", Nature, vol. 372, 190-193, Nov. 10, 1994.
Russell, G. et al., "Distinct structural and functional epitopes of the .alpha..sup.E .beta..sub.7 integrin", Eur. J. Immunol., 1994, 24: 2832-2841.

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