Human ubiquitin-conjugating enzymes

Details Human ubiquitin-conjugating enzymes Human ubiquitin-conjugating enzymes

1999-07-22

2000-11-14

Slobodyansky, Elizabeth

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

435 4, 435183, 530350, A61K 3843, C12N 900, C12Q 125, C07K 1447

Patent

active

061466247

ABSTRACT:
The invention provides a human ubiquitin-conjugating enzyme (HUBI) and polynucleotides which identify and encode HUBI. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUBI.

REFERENCES:
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Jentsch, Stefan, "The Ubiquitin-Conjugating System," Annu.Rev.Genet. (1992) 26:179-207.
Monia, B.P. et al., "Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins." J.Biol.Chem. (1989) 264:4093-4103.
van Nocker, S. et al., "The Arabidopsis Thaliana UBC7/13/14 Genes Encode a Family of Multiubiquitin Chain-forming E2 Enzymes." J.Biol.Chem. (1996) 271:12150-12158.
Llovera, M. et al., "Muscle Wasting Associated with Cancer Cachexia in Linked to an Important Activation of the ATP-Dependent Ubiquitin-Mediated Proteolysis" Int.J.Cancer (1995) 61:138-141.
Gregori, L. et al., "Ubiquitin-Mediated Degradative Pathway Degrades the Extracellular but not the Intracellular Form of Amyloid .beta.-Protein Precursor" Biochem.Biophys.Res.Commun. (1994) 203:1731-1738.
Grant, E.P. et al., "Rate of Antigen Degradation by the Ubiquitin-Proteasome Pathway Influences MHC Class I Presentation" J.Immunol. (155:3750-3758.
Kershaw, J., GI 1628097, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Kershaw, J., GI 1628091, GenBack Sequence Database (Accession U39318), National Center of Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Faye, G.R., GI 4257, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Faye, G.R., GI 4256, GenBank Sequence Database (Accession U39318), National Center for Biotechnolgy Information, National Library of Medicine, Bethesda, Maryland, 20894.

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