Phenylalanyl tRNA synthetase alpha subunit polynucleotides from

Details Phenylalanyl tRNA synthetase alpha subunit polynucleotides from Phenylalanyl tRNA synthetase alpha subunit polynucleotides from

1997-10-17

1999-02-16

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

058719890

ABSTRACT:
The invention provides pheS (alpha) polypeptides and DNA (RNA) encoding pheS (alpha) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pheS (alpha) polypeptides to screen for antibacterial compounds.

REFERENCES:
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) pp. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Brakhage et al., "Structure and Nucleotide Sequence of the Bacillus subtilis Phenylalanyl-tRNA Synthetase Genes," Biochime, 72 pp. 725-734 (1990).
Kreutzer R. et al., "Structure of the Phenylalanyl-tRNA Synthetase Genes from Thermus thermophilus HB8 and Their Expression in E. coli," Nucleic Acids Research, 20(1) pp. 4173-4178 (1992).
Fleischmann et al., "Whole-Genome Random Sequencing and Assembly of Haemophilus influenza Rd."Science, 269 pp. 496-512 (1995).

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