Nucleic acids encoding human neuronal attachment factor-1

Details Nucleic acids encoding human neuronal attachment factor-1 Nucleic acids encoding human neuronal attachment factor-1

1997-02-12

1999-02-16

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4352523, 4353201, 536 231, 536 235, C12N 1512, C12N 1563, C12N 1585

Patent

active

058719695

ABSTRACT:
A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

REFERENCES:
patent: 5279966 (1994-01-01), Jessell et al.
Hillier et al. GenBank Accession No. T81066, clone 1093535, 1995.

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