Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-02-19
1999-02-16
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C12Q 168
Patent
active
058719237
ABSTRACT:
Screening methods for identification of antimy-cotic agents active in mycotic cell translation, the agents identified thereby, and uses of these agents.
REFERENCES:
patent: 4792520 (1988-12-01), Stambrook et al.
Leppert et al., Genetics, vol. 125, 1990, pp. 13-20.
Balei et al., J. Biol. Chem., vol. 262, 1987, pp. 16871-16879.
Alani et al., "A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains," Genetics 116:541-545 (1987).
Balzi and Goffeau, "Multiple or pleiotropic drug resistance in yeast," Biochem. Biophys. Acta 1073:241-252 (1991).
Belcourt and Farabough, "Ribosomal Frameshifting in a Yeast Retrotransposon TY: tRNAs Induce Slippage on a 7 Nucleotide Minimal Site," Cell 62:339-352 (1990).
Boeke et al., A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast Saccharomyces cerevisiae: 5-fluoro-orotic acid resistance,: Mol. Gen. Genetics 197:345-346 (1984).
Brugge, "New Intracellular Targets for Therapeutic Drug Design," Science 260:918-919 (1993).
Cashel and Rudd, "The Stringent Response, Escherichia coli and Salmonella Typhimurium," Cellular and Molecular Biology, ed. F.C. Neidhardt (Washington D.C., American Society for Microbiology 1987) 2:1410-1438.
Chien et al., "The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest," Proc. Natl. Acad. Sci. USA 88:9578-9582 (1991).
Christianson et al., "Multifunctional yeast high-copy number shuttle vectors," Gene 110:119-122 (1992).
Clare and Oliver, "The Regulation of RNA Synthesis in Yeast," Mol. Gen. Genet. 188:96-102 (1982).
Clark, "New Approaches for Antifungal Drugs," ed. P.B. Fernandes (Boston:Birkhauser 1992) pp. 1-19.
Colthurst et al., "Elongation factor 3 (EF-3) from Candida albicans show both structural and functional similarity to EF-3 from Saccharomyces cerevisiae," Molecular Microbiology 6:1025-1033 (1992).
Colthurst et al., "Candida Albicans and three other Candida species contain an elongation factor structurally and functionally analogous to elongation factor 3," FEMS Microbiology Letters 80:45-50 (1991).
Dancis et al., Ferric reductase of Saccharomyces cervisiae: Molecular characterization, role in iron uptake, and transcriptional control, Proc. Natl. Acad. Sci. USA 89:3869-3873 (1992).
Dever et al., "Phosphorylation of Initiation Factor 2.alpha. by Protein Kinase GCN2 Mediates Gene-Specific Translational Control of GCN4 in Yeast," Cell 68:585-596 (1992).
Eberhart et al., "Species Differences in the Toxicity and Cytochrome P450 IIIA-Dependent Metabolism of Digitoxin," Mol. Pharmacol. 40:859-867 (1991).
Erickson and Johnston, "Direct Cloning of Yeast Genes from an Ordered Set of Lambda Clones in Saccharomyces cerevisiae by Recombination in vivo," Genetics 134:151-157 (1993).
Ezekial and Elkins, The Stimulation of Ribonucleic Acid Synthesis by Ribosome Inhibitors in Amino Acid-Starved Escherichia coli, Biochem. Biophys. Acta 166:466-474 (1968).
The Federal Register 47 (No. 56): 12558-12564 (1982).
Fields and Song, "A novel genetic system to detect protein-protein interactions," Nature 340:245-246 (1989).
Firoozan et al., "Quantitation of Readthrough of Termination Codons in Yeast using a Novel Gene Fusion Assay," Yeast 7:173-183 (1991).
Graybill, "New Antifungal Agents," Eur. J. Clin. Microbiol. Infect. Dis. 8:402-412 (1989).
Gross and Pogo, "Control of Ribonucleic Acid Synthesis in Eukaryotes 3. The Effect of Cycloheximide and Edeine on RNA Synthesis in Yeast," Biochemistry 15:2082-2086 (1976).
Hershey, "Translation Control in Mammalian Cells," C.C. Richardson ed., Ann. Rev. of Biochem. (Annual Review, Inc. 1991) 60:717-755.
Higgins et al., "Turnover of mRNA in prokaryotes and lower eukaryotes," Curr. Opin. in Gen. and Dev. 2:739-747 (1992).
Hinnebusch and Liebman, "Protein Synthesis and Translational Control in Saccharomyces cerevisiae," The Molecular Biology of the Yeast Saccharomyces, eds. J.R. Broach, J.R. Pringle and E.W. Jones (New York: CSH Laboratory Press, 1991) pp. 627-735.
Hinnenbush et al., "A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (2CYC1) of yeast," Proc. Natl. Acad. Sci. USA 82:498-502 (1985).
Huston and Logan, "Detoxification of the organophosphorus insecticide chlorfenvinphos by rat, rabbit and human liver enzymes," Xenobiotica 16:87-93 (1986).
Hwang et al., "Construction of a Promoter-Probe Vector with the PH05 Gene Encoding Repressible Acid Phosphate in Saccharomyces cerevisiae," Appl. Microbiol. Biotechnol. 28:155-159 (1988).
Hwang et al., "The Identification of a Domain in Escherichia coli Elongation Factor Tu That Interacts with Elongation Factor Ts," J. Biol. Chem. 267-22198-22205 (1992).
Hwang et al., "Mutagenesis of Bacterial Elongation Factor Tu at Lysine 136," J. Biol. Chem. 264:8304-8309 (1989).
Koltin, "Targets for Antifungal Drug Discovery," Annual Reports in Medicinal Chemistry, ed. James A. Bristol, Harcourt Brace Jovanovich, San Diego, Academic Press, Inc., 25:141-148 (1989).
Lanker et al., "Autoregulation of the Yeast Lysyl-tRNA Synthetase Gene Gcd5/KRS1 by Translation and Transcriptional Control Mechanisms," Cell 70:647-657 (1992).
Leeds et al., "Gene Products That Promote mRNA Turnover in Saccharomyces cerevisiae," Mol. Cell. Biol. 12:2615-2177 (1992).
Lindahl and Hinnebusch, "Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes," Curr. Opin. in Gen. and Dev. 2:720-726 (1992).
Merrick, "Mechanism and Regulation of Eukaryotic Protein Synthesis," Microbiological Reviews 56:291-315 (1992).
Min and Zassenhaus, "Identification of a Protein Complex That Binds to a Dodecamer Sequence Found at the 3' Ends of Yeast Mitochondrial mRNAs," Mol. Cell. Biol. 13:4167-4173 (1993).
Miranda et al., "Falvin-Containing Monooygenase: A Major Detoxifying Enzyme for the Pyrrolizidine Alkaloid Senecionine in guinea Pig Tissues," Biochem. Biophys. Res. Commun. 178:546-552 (1991).
Moehele and Hinnebusch, "Association of RAP1 Binding Sites With Stringent Control of Ribosomal Protein Gene Transcription in Saccharomyces cerevisiae," Mol. Cell. Biol. 11:2723-2735 (1991).
Nieuwint et al., "Mutational analysis of the upstream activation site of yeast ribosomal protein genes," Cell 71:97-105 (1992).
Nelson et al., "The Translation Machinery and 70 kd Heat Shock Protein Cooperate in Protein Synthesis," Current Genetics 15:247-251 (1989).
Oliver and McLaughlin, "The Regulation of RNA Synthesis in Yeast 1: Starvation Experiments," Mol. Gen. Genetics 154:145-153 (1977).
Paull et al., "The Synthesis of XTT: A New Tetrazolium Reagent that is Bioreducible to a Water-Soluble Formazan," J. Heterocyclic Chem. 25:911-914 (1988).
Pon and Schatz, "Biogenesis of Yeast Mitochondria," The Molecular Biology of the Yeast Saccharomyces, eds. J.R. Broach, J.R. Pringle, and E.W. Jones (New York: CSH Laboratory Press 1991) pp. 333-406.
Qin et al., "Sequence Analysis of the Translational Elongation Factor 3 From Saccharomyces cerevisiae," J. Biol. Chem. 265:1903-1912 (1990).
Rameriz et al., "Mutations Activating the Yeast elF-2.alpha. Kinase GCN2: Isolation of Alleles Altering the Domain Related to Histidyl-tRNA Synthetases," Mol. Cell. Biol. 12:5801-5815 (1992).
Ray and Butow, "Regulation of Mitochondrial Ribosomal RNA Synthesis in Yeast," Mol. Gen. Genet. 173:227-238 (1979).
Sandbaken et al., "Protein Synthesis in Yeast. Structural and functional analysis of the gene encoding elongation factor 3," J. Biol. Chem. 200:15838-15844 (1990).
Sandbaken et al., "Isolation and characterization of the structural gene encoding elongation factor 3," Biochem. Biophys. Acta 1050:230-234 (1990).
Siegel, "Effect of Fungicides on Protein Synthesis," Antifungal Compounds, sr. ed. Hugh D. Sister (New York, Marcel Dekker, Inc. 1977) vol. 2:399-348.
Sikorski and Hieter, "A System of Shuttle Vectors and Yeast Host Strains Designed for Efficient Manipulation of DNA in Saccharomyces cerevisiae," Genetics 122:19-27 (1989).
Silver and Bostian, "Screening of Natural Products for Antimicrobial Agents
Ketter James
RiboGene, Inc.
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