Immunassay of non-A, non-B hepatitis virus-related antigens, mon

Details Immunassay of non-A, non-B hepatitis virus-related antigens, mon Immunassay of non-A, non-B hepatitis virus-related antigens, mon

1995-07-11

1999-02-16

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 43524026, 43524027, 5303881, 5303883, C12Q 170, C12N 512, C07K 1608, C12P 2108

Patent

active

058719040

ABSTRACT:
This invention concerns a monoclonal antibody having binding specificity for an antigenic determinant site on core structural protein from Non-A,Non-B hepatitis virus (NANBV); a hybridoma cell line capable of producing the monoclonal antibody; a process for the preparation of the monoclonal antibody; an immunoassay of NANBV-related antigens by use of the monoclonal antibody; and a test kit for use in the immunoassay. The preferred monoclonal antibody is 5E3, 5F11, 515S or 1080S. The monoclonal antibody can specifically recognize the NANBV core structural protein in sera from patients with Non-A,Non-B hepatitis thereby being served extensively as an antibody in various immunological reagents for definitive diagnosis of Non-A, Non-B hepatitis.

REFERENCES:
patent: 5372928 (1994-12-01), Miyamura et al.
patent: 5437974 (1995-08-01), Ryan et al.
Geysen et al., "Cognitive Features of Continuous Antigenic Determinants", J. Mol. Recognit. 1(1)323-41 (1988).
Takahashi et al., "Demonstration of a hepatitis C virus-specific antigen predicted from the putative core gene in the circulation of infected hosts", J. Gen. Virol. 73, 667-672 (1992).
Siemonett, et al., Hybridoma vol. 13, No. 1, pp. 9-13 (1994).
Hiramatsu, et al., Hepatology, vol. 16, No. 2, pp. 306-311 (1992).
Takahashi, et al., J. of Gen. Virol., vol. 73, No. 3, pp. 667-672 (1992).
Kashiwakuma, et al., J. of Immun. Methods, vol. 190, No. 1, pp. 79-89 (1996).

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