Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1997-11-07
1999-02-16
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435238, 549282, A01N 102, C12N 706
Patent
active
058719008
ABSTRACT:
Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention compemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. In particular, 5'-primary amino psoralens are photoactivated in order to inactivate pathogens in biological fluids.
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Isaacs Stephen T.
Nerio Aileen
Rapoport Henry
Spielmann Hans Peter
Wollowitz Susan
Cerus Corporation
Saucier Sandra E.
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