Targeted adenovirus vectors

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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Details

514 44, 4351723, 4353201, C12N 500, C12N 1500, A61K 4800

Patent

active

058717277

ABSTRACT:
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene using a two-plasmid rescue system for derivation of adenoviral fiber recombinants.

REFERENCES:
patent: 5543328 (1996-08-01), McClelland et al.
Marshall, E (1995) Science 269: 1050-1055.
Miller et al (1995) FASEB J. 9 : 190-199.

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