Inhibitors of angiotensin converting enzyme

Details Inhibitors of angiotensin converting enzyme Inhibitors of angiotensin converting enzyme

1980-01-30

1987-09-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548531, 548535, A61K 3140, A61K 3141, C07D20700

Patent

active

046955828

ABSTRACT:
The compounds, N-[3-(benzoylphenylalanylthio)-2-D-methylpropanoyl]-L-proline (I), N-(2-benzoylphenylalanylthiopropanoyl)-L-proline (II) and N-(3-benzoylphenylalanylthiopropanoyl)-L-proline (III) are disclosed. These compounds are potent inhibitors of serum angiotensin converting enzyme.

REFERENCES:
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patent: 3865934 (1975-02-01), Plotnikoff
patent: 3891696 (1975-06-01), Bodor et al.
patent: 3947575 (1976-03-01), Ondetti
patent: 3973006 (1976-08-01), Ondetti
patent: 3975365 (1976-08-01), Mazur
patent: 3976770 (1976-08-01), Bunspus et al.
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4053651 (1977-10-01), Ondetti et al.

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