Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system
Patent
1996-01-31
1999-02-16
DeMille, Danton D.
Surgery
Controlled release therapeutic device or system
Implanted dynamic device or system
604132, 604153, 128DIG12, A61M 922
Patent
active
058714782
DESCRIPTION:
BRIEF SUMMARY
THIS INVENTION resides in a drug delivery means.
BACKGROUND OF THE INVENTION
In the treatment of patients it is often desirable to provide a means whereby a drug or like agent can be introduced in a controlled manner over an extensive period of time. With the conventional intake of drugs and the like by means of periodic ingestion of a capsule or tablet, or periodic injection, there is usually an initial increase in the amount of the active agent in the body which is then reduced over a period of time, until the next tablet is taken or injection given.
In many cases it is preferable to provide an intake of drug in a controlled manner such that the amount of drug in the body remains substantially constant. This is particularly the case in the treatment of patients suffering constant pain as in the case of terminally ill patients who require a constant amount of an analgesic to be administered in order for them to be able to withstand the pain.
In the past several devices have been proposed for controlling the introduction of the drug into a body whereby it can be delivered in a controlled manner over a period of time. Such devices have comprised pumps driven by a power source, and which controls the delivery of drug to the body. Some of these pumps may be mounted externally to the body and are connected to a catheter introduced to a the body of the patient. Other devices have comprised pump which is mounted subcutaneously to the body of the patient and which delivers a drug to the body at a desired location. Such devices suffer the disadvantage however they are quite expensive and that they utilize a power source in order to effect the delivery of the drug. In the event of the failure of the power source, the pump must be replaced. The power source has in the past taken a variety of forms including utilization of a phase-change fluid as is the case of a device marketed under the Trade Mark "INFUSAID".
Other delivery devices have comprised a manually operated pump which may be mounted externally to the body or subcutaneously in the body of the patient whereby the pump can be activated by the patient for the delivery of the drug as need arises for that drug. Examples of such devices are disclosed in U.S. Pat. Nos. 4,588,394, 4,681,560 and, 5,085,644 the contents of which are included herein by reference, and comprise devices whereby a pumping chamber is connected via catheter directly into the body and derives its source of drug from a holding reservoir. The pumping chambers are of the form whereby they are biassed to a maximum volume condition, and on activation by the patient it is moved to a minimum volume position. In the case of U.S. Pat. No. 5,085,644 the re-entry of the drug into the pumping chamber is controlled by means of a capillary such that the pump is only able to deliver a full volume after a predetermined period of time. The disadvantage with this form of delivery means however is that drug levels within the body will vary periodically whereby on activation of the pump, the drug level within the body initially has a high level which is then allowed to decay over a period of time until the pump is reactivated.
SUMMARY OF THE INVENTION
It is an object of this invention to provide a drug delivery means whereby the delivery of the drug to the patient can be controlled in order that there is a substantially constant delivery of the drug without the need for any form of a power source.
Accordingly the invention resides in a drug delivery means comprising a holding reservoir, a pump, a delivery reservoir and an outlet, said holding reservoir being connected to said delivery reservoir through said pump, said pump being operable manually whereby fluid is transferred from the holding reservoir to the delivery reservoir, said delivery reservoir being connected to the outlet through a flow restriction means which controls flow to the outlet, said delivery reservoir being formed to be resiliently expandable from a minimum volume to a maximum volume whereby the pressure induced on the fluid within the
REFERENCES:
patent: 4525165 (1985-06-01), Fischell
patent: 4588394 (1986-05-01), Schulte
patent: 4681560 (1987-07-01), Schulte
patent: 4714462 (1987-12-01), DiDomenico
patent: 4813951 (1989-03-01), Cannon
patent: 5053031 (1991-10-01), Borsanyi
patent: 5085644 (1992-02-01), Watson
LandOfFree
Implantable drug delivery means does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Implantable drug delivery means, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Implantable drug delivery means will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2058258