Radiation therapy method and device

Surgery – Radioactive substance applied to body for therapy – Radioactive substance placed within body

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424 111, 424 153, A61N 500

Patent

active

058714367

ABSTRACT:
An implantable medical device is used to deliver a dosage of radiation to a localized site within a patient. The device is coated with a chelator selected for its bonding affinity with a specific radioisotope. A base layer and optionally a spacer layer is first applied to the device to provide a proper foundation for the chelator. Just prior to implantation, the device is immersed in a solution of the radioisotope which enables a preselected amount of such radioisotope to be adsorbed.

REFERENCES:
patent: 4697575 (1987-10-01), Horowitz
patent: 4706652 (1987-11-01), Horowitz
patent: 4763671 (1988-08-01), Goffinet
patent: 4815449 (1989-03-01), Horowitz
patent: 4861520 (1989-08-01), van't Hooft et al.
patent: 4969863 (1990-11-01), van't Hooft et al.
patent: 4994560 (1991-02-01), Kruper, Jr. et al.
patent: 5002560 (1991-03-01), Machold et al.
patent: 5034001 (1991-07-01), Garrison et al.
patent: 5059166 (1991-10-01), Fischell et al.
patent: 5133956 (1992-07-01), Garlich et al.
patent: 5176617 (1993-01-01), Fischell et al.
patent: 5180368 (1993-01-01), Garrison
patent: 5199939 (1993-04-01), Dake et al.
patent: 5213561 (1993-05-01), Weinstein et al.
patent: 5263963 (1993-11-01), Garrison et al.
patent: 5300281 (1994-04-01), McMillan et al.
patent: 5302168 (1994-04-01), Hess
patent: 5320824 (1994-06-01), Brodack et al.
patent: 5354257 (1994-10-01), Roubin et al.
patent: 5411466 (1995-05-01), Hess
patent: 5456667 (1995-10-01), Ham et al.
patent: 5484384 (1996-01-01), Fearnot
patent: 5498227 (1996-03-01), Mawad
patent: 5503613 (1996-04-01), Weinberger
patent: 5503614 (1996-04-01), Liprie
patent: 5688486 (1997-11-01), Watson et al.
patent: 5730698 (1998-03-01), Fischell et al.
Lindsay, et al., Aortic Arteriosclerosis In The Dog After Localized Aortic X-Irradiation, Circulation Research, vol. X, Jan. 1964.
Friedman, et al., The Antiatherogenic Effect of Iridium.sup.92 Upon The Cholesterol-Fed Rabbit, Journal of Clinical Investigation (1964).
Friedman, et al., Effect Of Iridium 192 Radiation On Thromboatherosclerotic Plaque In The Rabbit Aorta, Arch Path, vol. 80, Sep. 1965.
Hoopes, et al., Intraoperative Irradiation Of the Canine Abdominal Aorta And Vena Cava, Journal of Radiation Oncology, vol. 13 (1987).
Dawson, Theoretic Considerations Regarding Low-Dose Radiation Therapy For Prevention Of Restenosis After Angioplasty, Texas Heart Institute Journal, vo.. 18, No. 1 (1991).
Schwartz, et al., Effect Of External Beam Irradiation On Neointimal Hyperplasia After Experimental Coronary Artery Injury, JACC, vol. 19, No. 5 (Apr. 1992).
Wiedermann, et al., Intracoronary Irradiation Markedly Reduces Restenosis After Balloon Angioplasty In A Porcine Model, JACC, vol. 23, No. 6 (1994).
Fischell, et al., Low-Dose .beta.-Particle Emission From `Stent` Wire Results In Complete, Localized Inhibition Of Smooth Muscle Cell Proliferation, Basic Science Reports (1994).
Waksman, et al., Endovascular Low-Dose Irradiation Inhibits Neointima Formation After Coronary Artery Balloon Injury In Swine -- A Possible Role For Radiation Therapy In Restenosis Prevention, Circulation, vol. 91, No. 5 (Mar. 1, 1995).
Weshler, et al., Inhibition By Irradiation Of Smooth Muscle Cell Proliferation In The De-Endothelialized Rat Aorta, Frontiers of Radiation Biology (1988).
Hehrlein, et al., Radioactive Stents, Discoveries in Radiation for Restenosis, Abstract 22 (Jan. 1996).
Fischell, et al., A Beta-Particle Emitting Radioisotope Stent For The Prevention Of Restenosis, Discoveries in Radiation for Restenosis, Abstract 23 (Jan. 1996).
Li, et al., A Novel Brachyehtapy Source For Treatment of Coronary Artery Restenosis, Discoveries in Radiation for Restenosis, Abstract 24 (Jan. 1996).
Waksman, Catheter-Based Radiation In Stented Arteries, Discoveries in Radiation for Restenosis, Abstract 25 (Jan. 1996).
Martin, Radiation For Peripheral Applications: Technical Aspects, Discoveries in Radiation for Restenosis, Abstract 27 (Jan. 1996).
Lumsden, et al., Restenosis In Peripheral Vascular Disease, Discoveries in Radiation for Restenosis, Abstract 28 (Jan. 1996).
Schopohl, et al., Endovascular Irradiation For Avoidance of Recurrent Stenosis After Stent Implantation in Peripheral Arteries -- 5 Years Follow-Up, Discoveries in Radiation for Restenosis, Abstract 29 (Jan. 1996).
Waksman, Radiation In The Peripheral System At Emory, Discoveries in Radiation for Restenosis, Abstract 30 (Jan. 1996).
Teirstein, et al., Catheter-Based Radiation Therapy To Inhibit Restenosis Following Coronary Stenting, Discoveries in Radiation for Restenosis, Abstract 31 (Jan. 1996).
King, Clinical Restenosis Trials Using Beta Energy Radiation, Discoveries in Radiation for Restenosis, Abstract 32 (Jan. 1996).
Urban, et al., Endovascular Irradiation With 90Y Wire, Discoveries in Radiation for Restenosis, Abstract 33 (Jan. 1996).
Condado, et al., Late Follow-Up After Percutaneous Transluminal Coronary Angioplasty (PTCA) And Intracoronary Radiation Therapy (ICRT), Discoveries in Radiation for Restenosis, Abstract 34 (Jan. 1996).
Weldon, Catheter Based Beta Radiation System, Discoveries in Radiation for Restenosis, Abstract 35 (Jan. 1996).
van't Hooft, et al., HDR Afterloader For Vascular Use, Discoveries in Radiation for Restenosis, Abstract 36 (Jan. 1996).
Fischell, et al., The Radioisotope Stent: Conception And Implementation, Discoveries in Radiation for Restenosis, Abstract 37 (Jan. 1996).
Popowski, et al., Radioactive Wire In A Self-Centering Catheter System, Discoveries in Radiation for Restenosis, Abstract 38 (Jan. 1996).
Calfee, High Dose Rate Afterloader System For Endovascular Use -- Neocardia, Discoveries in Radiation for Restenosis, Abstract 39 (Jan. 1996).
Smith, Issues On Handling Radioactive Devices To Prevent Restenosis, Discoveries in Radiation for Restenosis, Abstract 40 (Jan. 1996).
Kuntz, et al., Generalized Model Of Restenosis After Conventional Balloon Angioplasty, Stenting and Directional Atherectomy, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Schwartz, et al., Differential Neointimal Response To Coronary Artery Injury In Pigs And Dogs, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Haude, et al., Quantitative Analysis Of Elastic Recoil After Balloon Angioplasty And After Intracoronary Implantation Of Balloon-Expandable Palmaz-Schatz Stents, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Kakuta, et al., Differences In Compenstory Vessel Enlargement, Not Intimal Formation, Account For Restenosis After Angioplasty In The Hypercholesterolemic Rabbit Model, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Unterberg, et al., Reduced Acute Thrombus Formation Results In Decreased Neointimal Proliferation After Coronary Angioplasty, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Byhardt, et al., The Heart And Blood Vessels, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Soares, et al., Measurement Of Radial Dose Distributions Around Small Beta Particles Emitters Using High Resolution Radiochromic Foil Dosimetry, collected in Discoveries in Radiation for Restenosis --Selected Literature (Jan. 1996).
Schwartz, et al., Effect Of External Beam Irradiation On Neointimal Hyperplasia After Experimental Coronary Artery Injury, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Waksman, et al., Endovascular Low-Dose Irradiation Inhibits Neointima Formation After Coronary Artery Balloon Injury In Swine, etc., collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Wiedermann, et al., Intracoronary Irradiation Markedly Reduces Restenosis After Balloon Angioplasty In a Porcine Model, collected in Discoveries in Radiation for Restenosis -- Selected Literature (Jan. 1996).
Wiedermann, et al., Intracoronary Irradiation Markedly Reduces Neointimal Proliferation After Balloon Angioplasty In Swine: Persistent Benefit At 6-Month Follow-Up, collected

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