Process for the preparation of nitropyrazole esters

Details Process for the preparation of nitropyrazole esters Process for the preparation of nitropyrazole esters

1997-07-07

1999-10-19

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483714, 5483731, 5483741, C07D23116, C07D23114

Patent

active

059691522

ABSTRACT:
Nitropyrazole esters of the formula ##STR1## in which R.sup.1 represents C.sub.1 -C.sub.6 -alkyl, are prepared by nitration of the corresponding pyrazole esters. The nitropyrazole esters permit the preparation of a known nitropyrazole amide in a particularly simple and economical manner and thereby improve the preparation of active compounds which are accessible from the nitropyrazole amide.

REFERENCES:
patent: 4145554 (1979-03-01), Jones et al.
patent: 4172136 (1979-10-01), Berger et al.
patent: 4317823 (1982-03-01), Rainer
patent: 4810283 (1989-03-01), Gehring et al.
Chemical Abstracts, vol. 52, No. 1, Jan. 10, 1958, Columbus, Ohio, US; Robins, et al.: "Potential purine and antagonists . . . ", Spalte 395; XP002047057 & J. Org. Chem., 21, 833-836 (1956), *Zusammenfassung*.
Musante, pp. 121-123. Gazz. Chim. Ital., 75 (1945).
P. Giovanni Baraldi, et al., Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogues of Pyrrolo[1,4][2,1-c]benzodiazepines, J. Med. Chem., vol. 37, No. 25, pp. 4329-4337, (1994).
G.J. Ellames, et al., The Syntheses of Acycloformycins and 5-Amino-3-(2-hydroxyethoxy)-methylpyrazolo[4,3-d]pyrimidin-7(6H)-one, an Analogue of the Antiviral Acycloguanosine, J. Chem. Soc. Perkin. Trans. I, pp. 2087-2091, (1985).
Musante, Su alcuni acidi pirazolcarbonici e loro derivati, pp. 121-136. Gazz. Chim. Ital., 75 (1945).
J. Wierzchowski, et al., Analogues of formycins A and B: synthesis and some properties of methyl derivatives of 7-amino and 7-keto pyrazolo(4,3-d)pyrimidines*, Acta Biochimica Polonica, vol. 27, No. 1, pp. 35-56, (1980).

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