Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-04-08
1999-10-19
Mertz, Prema
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 53038823, 5303891, 5303892, 435325, 435326, 435331, 435335, C07K 1624
Patent
active
059691107
ABSTRACT:
Antibodies specific for a hek-L may be generated, using a hek-L polypeptide or fragment thereof as an immunogen. The antibodies may be monoclonal.
REFERENCES:
patent: 5185438 (1993-02-01), Lemischka
patent: 5599669 (1997-02-01), Dixit
patent: 5728813 (1998-03-01), Lyman et al.
Cerretti et al., "Isolation of cDNAs that Encode Ligands to the Receptor Tyrosine Kinases Hek and Elk: Emergence of a Family of Proteins that are Ligands for the Eph Related Kinases (LERKS"), Abstract for American Assoc. for Cancer Research conference on Growth Factors, Development, and Cancer, held in Interlaken Switzerland, Mar. 5-11, 1994.
Boyd et al. "Isolation and Characterization of a Novel Receptor-type Protein Tyrosine Kinase (hek) from a Human Pre-B Cell Line", J. Biol. Chem. 267: 3262-3267, 1992.
Wicks et al., "Molecular Cloning of the HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines", Proc. Natl. Acad. Sci. USA 89: 1611-1615, 1992.
Wicks et al., "Molecular Characterisation of HEK, a Novel Human Receptor Tyrosine Kinase", Thesis for degree of Doctor of Philosophy, University of Melbourne, submitted Apr. 1992.
Lhotak et al., "Characterization of Elk, a Brain-Specific Receptor Tyrosine Kinase", Mol. Cell. Biol. 11: 2496-2502, 1991.
Letwin et al., "Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody", Oncogene 3: 621-627, 1988.
Sajjadi et al., "Identification of a New eph-Related Receptor Tyrosine Kinase Gene From Mouse and Chicken that is Developmentally Regulated and Encodes at Least Two Forms of the Receptor", New Biol. 3: 769-788, 1991.
Chan and Watt, eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases, Oncogene 6: 1057-1061, 1991.
Lindberg et al., "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases", Mol. Cell. Biol., 10: 6316-6324, 1990.
Pasquale, "Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family", Cell Regulation 2: 523-534, 1991.
Hirai et al., "A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene", Science 238: 1717-1720, 1987.
Byrn et al., "Biological properties of a CD4 immunoadhesin", Nature 344: 667-670, 1990.
Ashkenazi et al., "Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin", Proc. Natl. Acad. Sci. USA 88: 10535-10539, 1991.
Holzman et al., "A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein", Mol. Cell. Biol. 10: 5830-5838, 1990.
Ferguson and Williams, "Cell-Surface Anchoring of Proteins via Glycosyl-Phosphatidylinositol Structures", Ann. Rev. Biochem. 57: 285-320, 1988.
Bohme et al., "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2", Oncogene 8: 2857-2862, 1993.
Bowie et al., "Deciphering the Message in Protein Sequences: Tolerance to AminoAcid Substitutions", Science vol. 247: 1306-1310, 1990.
Holzman et al. (1990) Mol. & Cell. Biology vol. 10, pp. 5830-5838.
Lenner (1982) Nature vol. 299, pp. 592-596.
Harlow et al. (1988) Antibodies a Laboratory Manual Cold Spring Harbor Laboratory, Chapter 5, p. 76.
Beckmann M. Patricia
Cerretti Douglas P.
Anderson Kathryn A.
Immunex Corporation
Mertz Prema
LandOfFree
Antibodies that bind hek ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies that bind hek ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies that bind hek ligands will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2056921