Anti-idiotypic antibodies which induce an immune response agains

Details Anti-idiotypic antibodies which induce an immune response agains Anti-idiotypic antibodies which induce an immune response agains

1996-05-24

1999-10-19

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303877, 5303881, 53038823, 5303888, 53038885, 5303873, 4241301, 4241311, 4241381, 4241411, 4241521, 4241551, 4241721, 4241741, C07K 1600, A61K 39395

Patent

active

059691077

ABSTRACT:
The present invention relates to anti-idiotypic antibodies which induce an immune response against tumors, bearing as antigen the epidermal growth factor receptor (EGFR). The antibodies of the invention may mimic said antigen. As preferred embodiment the antibodies of the invention derive from mAB 425 (ATCC HB 9629) or a humanized or chimeric derivative thereof.

REFERENCES:
patent: 4918164 (1990-04-01), Hellstrom et al.
patent: 5344760 (1994-09-01), Harvey et al.
patent: 5459061 (1995-10-01), Sato et al.
Chanh et al (PNAS, 84;3891-3895), 1987.
Rodeck et al., "Monoclonal Antibody 425 Inhibits Growth Stimulation . . . ", J. of Cellular Biochemistry, vol. 44:69-79, 1990.
Kettleborough et al., "Humanization of a mouse monoclonal antibody . . . ", Protein Engineering, 4(7):773-783, 1991.
Murthy et al., "Binding of an Antagonistic Monoclonal Antibody to . . . ", Archives of Biochemistry and Biophysics, 262(2):549-560, 1987.
Carter et al., "Humanization of an anti-p185.sup.HER2 antibody for . . . ", Proc. Natl. Acad. Sci. USA, vol. 89:4285-4289, 1992.
Rodeck et al., "Tumor Growth Modulation by a Monoclonal Antibody to . . . ", Cancer Research, vol. 47:3692-3696, 1987.
Merimsky et al., "Antigens and Antibodies in Malignant Melanoma," Tumor Biol., 15:188-202, 1994 [and Abstract].
Steiner et al., "Distribution of Humanized MAb 425 (EMD 62 000) . . . ," Cellular and Molecular Biology, 41(1):179-184, 1995.
Tsujusaki et al., "The Analysis of Internal Image-Bearing . . . ," J. of Immun., 15(2):508-516, Jan. 15, 1993.
Suarez et al., "Anti-idiotype monoclonal antibodies recognizing . . . ," Immunologia:Monoclonal Antibody Rpts., 12:122-123, 1993.
Queen et al CPNAS, 1989, 86: 10029-10033.

Affiliated with

Also associated with

Rating

Anti-idiotypic antibodies which induce an immune response agains does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-idiotypic antibodies which induce an immune response agains, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-idiotypic antibodies which induce an immune response agains will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2056835