Nucleic acid encoding a novel homeobox factor which stimulates i

Details Nucleic acid encoding a novel homeobox factor which stimulates i Nucleic acid encoding a novel homeobox factor which stimulates i

1996-01-05

1998-04-21

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 435325, 4353201, 536 235, 536 2431, C12N 1512

Patent

active

057416737

ABSTRACT:
In accordance with the present invention, there are provided novel homeobox-type pancreatic islet transcription factor proteins useful to bind to tissue-specific elements (TSEs) within a pancreatic islet hormone gene promoter and modulate hormone gene expression both in vivo and in vitro. Nucleic acid sequences encoding such transcription factor proteins and assays employing same are also disclosed. The invention transcription factor proteins can be employed in a variety of ways, for example, to modulate RNA transcription, for production of antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies.

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Ohlsson and Edlund, "Sequence-Specific Interactions of Nuclear Factors with the Insulin Gene Enhancer," Cell 45:35-44 (1986).
Vallejo et al., "Somatostatin Gene Transcription Regulated by a Bipartite Pancreatic Islet D-cell-specific Enhancer Coupled Synergetically to a cAmp Response Element," The Journal of Biological Chemistry 267:12868-12875 (1992).
Wedeen et al., "Evidence for a new family of evolutionarily conserved homeobox genes," Nucleic Acids Research 18:1908 (1990).
Wright et al., "XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm," Development 105:787-794 (1989).

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