Substituted guanidines and derivatives thereof as modulators of

Details Substituted guanidines and derivatives thereof as modulators of Substituted guanidines and derivatives thereof as modulators of

1995-06-05

1998-04-21

Leary, Louise

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

424570, 424 111, 436503, 436 86, 436504, 514634, 514 20, 564230, C12Q 102, A23J 300, A01N 3752

Patent

active

057416613

ABSTRACT:
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.

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