Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-02-23
1999-10-19
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514317, 514318, 514343, 514422, 514423, A61K 31445, A61K 3144, A61K 3140
Patent
active
059689579
ABSTRACT:
This invention relates to a method of using neurotrophic low molecular weight, small molecule piperidine and pyrrolidine sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
REFERENCES:
patent: 4692458 (1987-09-01), Ryan et al.
patent: 4734420 (1988-03-01), Ryan et al.
patent: 4745124 (1988-05-01), Ryan et al.
patent: 5229387 (1993-07-01), Clark et al.
patent: 5585397 (1996-12-01), Tung et al.
patent: 5614547 (1997-03-01), Hamilton et al.
patent: 5696135 (1997-12-01), Steiner et al.
patent: 5721256 (1998-02-01), Hamilton et al.
patent: 5786378 (1998-07-01), Hamilton et al.
patent: 5795908 (1998-08-01), Hamilton et al.
patent: 5798355 (1998-08-01), Steiner et al.
patent: 5801187 (1998-09-01), Li et al.
patent: 5801197 (1998-09-01), Steiner et al.
Holt et al., "Structure-Activity Studies of Synthetic FKBP Ligands as Peptidyl-Prolyl Isomerase Inhibitors," Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 2, pp. 315-320, 1994.
Dumont, Francis J. et al., "The Immunosuppressive and Toxic Effects of FK-506 are Mechanistically Related: Pharmacology of a Novel Antagonist of FK-506 and Rapamycin," J. Exp. Med., 1992, 176, 751-760.
Schreiber, Stuart L., "Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands," Science, 1991, 251, 282-287.
Hamilton Gregory S.
Li Jia-He
Steiner Joseph P.
GPI Nil Holdings Inc.
Jarvis William R. A.
Juneau Todd L.
Nath Gary M.
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