Method for the prevention of coronary artery spasm

Details Method for the prevention of coronary artery spasm Method for the prevention of coronary artery spasm

1997-10-17

1999-10-19

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514369, 514652, A61K 3158

Patent

active

059689188

ABSTRACT:
The present invention relates to the prevention of coronary artery spasm in mammals by the administration of an effective amount of an antiestrogen compound to block estrogen receptors for the reduction or prevention of the formation of an estrogen--estrogen receptor complex so that estrogen response elements in the DNA of the smooth muscle of the coronary arteries is not activated by the complex. The method of the invention is used to reduce the risk of spasm induced cardiac problems such as sudden infant death syndrome. The antiestrogen is selected from the group consisting of progestins and nonsteroidal antiestrogen compounds.

REFERENCES:
patent: 4729999 (1988-03-01), Young
patent: 5472985 (1995-12-01), Grainger et al.
patent: 5512557 (1996-04-01), Collins
patent: 5733925 (1998-03-01), Knuz et al.
I. Kanda, M. Endo Coronary Artery Spasm: a Hypothesis on Prevention by Progesterone, Medical Hypothesis, 49, 183-185, Aug. 1997.

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