Resorufin derivatives

Details Resorufin derivatives Resorufin derivatives

1991-03-28

1994-04-19

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 31435, A61K 31495

Patent

active

053046455

ABSTRACT:
The present invention provides resorufin derivatives of the general formulae: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which can be the same or different, are hydrogen, halogen, carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups or lower alkyl or lower alkoxy radicals, which can be substituted by carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups, and wherein R.sup.4 and R.sup.5 can together also represent an anellated aromatic residue, Z is a bridge member, A is the residue of a ligand and n is a whole number of from 1 to 200.
The present invention also provides processes for the preparation of these resorufin derivatives, as well as intermediates for the preparation thereof.

REFERENCES:
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patent: 4667032 (1987-05-01), Lau et al.
patent: 4859667 (1989-08-01), Lau et al.
patent: 4900822 (1990-02-01), Eltz et al.
patent: 4954630 (1990-09-01), Klein et al.
patent: 5242805 (1993-09-01), Naleway et al.
Ried, W., et al. (1972) Liebigs Ann. Chem. 764:11-20.
Bird, C. W., et al. (1979) Tetrahedron 36:529-533.

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