Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-04-08
1999-10-19
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 91, 514 95, 514 99, 546 21, 548412, 548413, 549 5, 549 6, 549216, 549218, 562 8, 562 12, C07F 958, C07F 9572, C07F 96553, A61K 31675
Patent
active
059689153
ABSTRACT:
The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme which is a membrane-bound metalloprotease which hydrolyzes the dipeptide, N-acetyl-L-aspartate-L-glutamate (NAAG) to yield glutamate and N-acetylaspartate. The compounds of the present invention include phosphinic acid derivatives that inhibit NAALADase enzyme activity and which have been found useful for inhibiting the growth of prostate cancer cells.
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Jackson Paul F.
Slusher Barbara S.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Nath Gary M.
Rotman Alan L.
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