Precursors for deoxyribonucleotides containing non-standard nucl

Details Precursors for deoxyribonucleotides containing non-standard nucl Precursors for deoxyribonucleotides containing non-standard nucl

1996-12-31

2000-10-31

Arthur, Lisa B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, C07H 1900

Patent

active

061404969

ABSTRACT:
The disclosure describes building blocks for preparing oligonucleotides carrying non-standard nucleobases that can pair with complementary non-standard nucleobases so as to fit the Watson-Crick geometry, in that the resulting base pair joins a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six member ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").

REFERENCES:
patent: 5177064 (1993-01-01), Bodor
patent: 5412088 (1995-05-01), Jones et al.
patent: 5470974 (1995-11-01), Summerton et al.
Switzer et al. J. Am. Chem. Soc. (1989) 111:8322-8323.
Randerath et al. Meth. in Enzymology (1980) 65: 638-680.
Golas et al. Int. J. Biochem (1976) 65: 183-192.
Sepiol et al. Z. Naturforsch (1976) 31e: 361-370.
Cobianchi, F. et al. Methods in Enzymology (1987) 152: 94-110.
Eritia et al. Nucl. Acids Res. (1986) 14(20): 8135-8153.
Chen, J. et al. Biochemistry (1988) 27: 6032-6038.
Cech, T. et al. Ann. Rev. Biochem (1986) 55:599-629.
Szostak, J. Nature (1986) 322:83-86.
Froehler, B.C. et al. Nucl. Acids. Res. (1983) 11(22): 8031-8036.
Langer, P.R. et al. PNAS (1981) 78(11): 6633-6637.
Larson, K. et al. Mutation Res. (1985) 150: 77-84.
Krosigk et al. J. Am. Chem. Soc. (1995) 117: 5361-5362.
Voegel, J.J. et al. J. Org. Chem. (1993) 58: 7542-7547.
Sarver, N. et al. Science (1990) 247: 1222-1225.
Switzer et al. Biochem. (1993) 32: 10489-10496.
Haseloff et al. Nature (1988) 334: 585-591.
Been, M.D. et al. Science (1988) 239: 1412-1416.
Mantsch, H.H. et al. Biochem. (1975) 14(26)5593-5601.
Bain, J.D. et al. J. Am. Chem. Soc. (1989) 111: 8014-8014.
Kimura, J. et al. Bull. Chem. Soc. Jpn (1980) 53: 3670-3677.
Chu, C.K. et al. J. Org. Chem (1977) 42(4) 711-714.
Noren, C.J. et al. Science (1989) 244: 182-188.
Leary, J.J. et al. PNAS. (1983) 80: 4045-4049.
Sgaramella, V. et al. J. Mol. Biol. (1972) 72: 427-444.
Zubay, G. Roots of Modern Biochem. pp. 911-916 eds. Klein Kauf, von Dohren, Jeanicke. 1988. Walter de Gruyter & Co Berlin.
Watanabe et al. in Nucleic Acid Chemistry. eds. Tipson, Townsend John Wiley & Sons, New York, 1978. pp. 273-277.
Piccirilli et al. Nature 343: 33-37, Jan. 4, 1990.

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