Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1999-02-18
2000-10-31
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
435134, A61K 3120, C12P 764
Patent
active
061403652
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
Preparation of microorganisms comprising omega-3-fatty acids for use as a prophylactic or therapeutic agent against parasitic diseases of animals
The present invention relates to the use of a preparation containing omega-3-fatty acid for preparing a medicament for prophylactic and therapeutic use against a parasitic disease of animals.
Omega-3-fatty acids (omega-3-polyunsaturated fatty acids=omega-3-PUFAs), in particular EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have recently become more and more important for the human diet. They have positive dietary and health-enhancing effects. With respect to lowering the cholesterol level and reducing the frequency of cardiovascular disorders, it is sensible to enrich the human diet with omega-3-fatty acids. The positive effect of omega-3-PUFAs on pathological metabolic processes has been demonstrated in a large number of studies. Moreover, docosahexaenoic acid plays an important role as a building block in the central nervous system (brain) and in the retina.
Hitherto, except for fish breeding, there have been relatively few investigations into the significance of omega-3-PUFAs in the field of animal health. Up to now, omega-3-PUFA preparations have been primarily administered to animals via the feed with the intention of enriching certain animal products (eggs, meat) intended for human consumption with omega-3-PUFAs. Thus, the omega-3-PUFA content of the fatty tissues of the muscles of poulards could be increased significantly by feeding them a PUFA-containing product (Mooney & van Elswyk, 1995, Poultry Science 74, Suppl. 1, 89). Furthermore, it was shown that it is possible to enrich eggs with omega-3-PUFAs by enriching the feed of laying hens with omega-3-PUFA-containing components (linseed oil, rapeseed oil, soya oil, fish oil) (Herber & van Elswyk, 1995, Poultry Science 74, Suppl. 1, S. 57;
Grashorn and Blanch 1996, DGS 6, 6-9).
Hitherto, there have been no investigations into the use of omega-3-PUFA preparations in the context of prophylactic and therapeutic measures for controlling parasitic diseases of useful animals. In modern poultry farming, coccidiosis caused by a certain protozoan species (order Eimeria) has great practical economical importance as an intestinal disease, owing to the high proportion of losses. In a study which has recently been published, it was shown that the course of a coccidia infection can be influenced positively by enriching the feed with fish oil (reduction in the number/intensity of the lesions in the intestine, reduction in weight loss) (Muirhead, 1995, Feedstuffs, Nov. 6 1995, 12). This effect was ascribed to the action of the omega-3-PUFAs present in fish oil.
Worm infections are widespread throughout the world among agriculturally useful animals and lead to economic losses, in particular among young animals.
Omega-3-PUFA preparations develop, in the digestive tract, an activity directed against helminths (worms) which parasitize there.
However, the use of fish oil as a source of omega-3-fatty acids is not unproblematic since, in addition to a number of other fatty acids, cholesterol and certain heavy metals are also present in fish oil. Moreover, the composition of the PUFA content varies, in some cases considerably, depending on the kind of fish, the season and the fishing area, which makes the preparation of PUFA products with a uniform concentration content from fish difficult. Furthermore, fish oil can be employed in the feed diets only in a limited amount, owing to the effect on the end products in terms of taste and smell. A further problem which has to be emphasized is the fact that the omega-3-PUFA concentration in fish oil is usually at most 15-20%, and it is technically very difficult to concentrate the fatty acids, which is necessary for preparing a feed additive.
The present invention solves the abovementioned problems by using aquatic microorganisms (microalgae, protozoa, fungi, bacteria) as production strains for preparing preparations comprising omega-3-PUFAs, in particular eico
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Kiy Thomas
Klein Ulrich
Mullner Stefan
Wullbrandt Dieter
Adventis Research & Technologies GmbH & Co. KG
Weddington Kevin E.
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