Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-24
2000-10-31
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514320, 514337, 544368, 544370, 544376, 544377, 546196, 546199, 5462737, 5462744, 5462827, 5462831, 5462841, A61K 31445, A61K 31495, C07D40504, C07D40514
Patent
active
061403318
ABSTRACT:
##STR1## Fused benzo compounds of formula (I), wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from SO, SO.sub.2, and a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroatoms; R.sup.1 is an aliphatic hydrocarbon group, arylalkyl or diphenylalkyl; R.sup.2 and R.sup.3 are hydrogen or alkyl or together form an ethylene or propylene bridge; R.sup.4, R.sup.5 and R.sup.6 are hydrogen or substituents; R.sup.7 and R.sup.8 are hydrogen or substituents including, a group --COOR.sup.9 and a group --CONR.sup.10 R.sup.11 ; are 5-HT.sub.1A receptor ligands useful in the treatment of CNS disorders. Pharmaceutical compositions comprising the compounds and their use for the manufacture of a pharmaceutical preparation are also disclosed.
REFERENCES:
patent: 4216216 (1980-08-01), Weber et al.
patent: 4302592 (1981-11-01), Teiman
patent: 4506078 (1985-03-01), Batcho
patent: 4831031 (1989-05-01), Lowe, III et al.
patent: 4950670 (1990-08-01), Frost et al.
patent: 5424313 (1995-06-01), Hartog et al.
patent: 5439922 (1995-08-01), Perregaard et al.
D.E. Boswell et al., Journal of Heterocyclic Chemistry (1968), vol. 5, No. 1, pp. 69-75.
Eric F.V. Scriven et al., Journal of the Chemical Society, Perkins Transactions 1 (1979), pp. 53-59.
L. Lee Melhado et al., Journal of Organic Chemistry 48 (1983), pp. 5130-5133.
Mark D. Tricklebank et al., European Journal of Pharmacology (1985), vol. 117, pp. 15-24.
Torben Skarsfeldt et al., European Journal of Pharmacology (1986), vol. 125, pp. 333-340.
Mark D. Tricklebank et al., European Journal of Pharmacology (1987), vol. 133, pp. 47-56.
Ineke van Wijngaarden et al., Journal of Medicinal Chemistry (1988), vol. 31, pp. 1934-1940.
C.G. Kruse et al., Recueil des Travaux Chimiques des Pays-Bas (1988), vol. 107, No. 4, pp. 303-309.
Luigi Cervo et al., European Journal of Pharmacology (1988), vol. 158, pp. 53-59.
Richard A. Gillis et al., The Journal of Pharmacology and Experimental Therapeutics (1988), vol. 248, No. 2, pp. 851-857.
Gregory E. Martin et al., Journal of Medicinal Chemistry (1989), vol. 32, pp. 1052-1056.
Debra A. Glitz et al., Drugs (1991), vol. 41, No. 1, pp. 11-18.
Jochen H.M. Prehn et al., European Journal of Pharmacology (1991), vol. 203, pp. 213-222.
A. van Hest et al., Psychopharmacology (1992), vol. 107, pp. 474-479.
Connie Sanchez et al., Psychopharmacology (1993), vol. 110, pp. 53-59.
Boddeke, Henrikus W.G.M. et al., "Agonist/antagonist interactions with cloned human 5-HT.sub.1A receptors: variations in intrinsic activity studied in transfected HeLa cells," Naunyn-Schmiedeberg's Arch. Pharmacol., (1992), 345(3)257-63 (abstract).
Glennon, Richard A. et al., "Arylpiperazine Derivatives as High Affinity 5-HT.sub.1A Serotoin Ligands," Journal of Medical Chemistry, vol. 31, No. 10 (1988), pp. 1968-1971.
Hyttell, John et al., "Neurochemical Profile In Vitro of Irindalone:A 5-HT.sub.2 -Receptor Antagonist," Drug Development Research 15 (1988), pp. 389-404.
Hyttell, John et al., "Neurochemical Profile of Lu 19-005, a Potent Inhibitor of Uptake of Dopamine, Noradrenaline, and Serotonin," Journal of Neurochemistry, vol. 44, No. 5 (1985), pp. 1615-1622.
Moltzen Ejner K.
Pedersen Henrik
Perregaard Jens
Coleman Brenda
H. Lundbeck A/S
Shah Mukund J.
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