Method of detecting or identifying ligands, inhibitors or promot

Details Method of detecting or identifying ligands, inhibitors or promot Method of detecting or identifying ligands, inhibitors or promot

1996-09-10

2000-10-31

Mertz, Prema

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435325, 530350, 530351, 5303879, G01N 3353, C12N 500, C07K 1400, C07K 1600

Patent

active

061400645

ABSTRACT:
The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.

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