N-propylnorapomorphine diesters

Details N-propylnorapomorphine diesters N-propylnorapomorphine diesters

1976-12-13

1978-11-21

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424258, C07D21520, C07D21522

Patent

active

041266161

ABSTRACT:
N-Propylnorapomorphine dialkanoate, dibenzoate and dicyclopropanecarboxylate esters and acid-addition salts thereof, having anti-parkinson activity, are prepared by reaction of N-propylnorapomorphine with a respective alkanoyl, benzoyl or cyclopropanecarbonyl halide or corresponding acid anhydride in the presence of an acid acceptor.

REFERENCES:
patent: 3717639 (1973-02-01), Neumeyer
patent: 3717643 (1973-02-01), Archer
Lecomte et al., Chem. Abstracts, vol. 58, 6104d (1962).
Ibid Janssen et al., vol. 55, 8659f (1960).
Cannon et al. "J. Pharm Sci."52(11), 1112-1113 (1963).
Dictionary of Organic Compounds, Oxford Press (1965).

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