Monoclonal antibodies to cachectin/tumor necrosis factor and met

Details Monoclonal antibodies to cachectin/tumor necrosis factor and met Monoclonal antibodies to cachectin/tumor necrosis factor and met

1995-06-07

1997-12-16

Loring, Susan A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435335, 435326, 435340, 435346, 53038823, 5303884, 5303871, C12P 2108, C12N 512, C07K 1624, C07K 1618

Patent

active

056984197

ABSTRACT:
The present invention pertains to the novel hybridoma SDW18.1.1, hybridomas obtained from SDW18.1.1, monoclonal antibodies obtained from such hybridomas and derivatives of such monoclonal antibodies. The novel hybridomas are formed by fusion of cells from a mouse myeloma line and spleen cells from a mouse previously immunized with cachectin/TNF. Diagnostic and therapeutic utilities for the monoclonal antibodies and their derivatives are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.

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