Process for obtaining para-cresol and meta-cresol from a mixture

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568750, C07C 3768, C07C 3774

Patent

active

042673909

ABSTRACT:
A process is disclosed for the stepwise separation of para-cresol and meta-cresol from a mixture of methylated and ethylated phenols. The para-cresol forms a complex with a dehydrated or anhydrous inorganic halide salt selected from the group consisting of calcium bromide, lithium bromide, manganese bromide and magnesium chloride. The meta-cresol isomer is separated from the mixture by formation of a complex with sodium acetate. Where the anhydrous or dehydrated inorganic halide salt is added firstly to the mixture of methylated and ethylated phenols including para-cresol and meta-cresol, the halide salt is provided in an amount to give a mole ratio of the halide salt to para-cresol in the mixture in the range of about 0.5 to one to about 1.5 to one. The para-cresol complexes with the halide salt and the complex is then removed from the mixture. The para-cresol-salt complex is thereafter decomposed to recover the para-cresol. The mixture of methylated and ethylated phenols including meta-cresol from which the para-cresol has been removed has added to it sodium acetate in an amount to give a mole ratio of sodium acetate to meta-cresol in the mixture in the range of about 0.5 to one to about 5 to one. The meta-cresol sodium acetate complex is then separated from the mixture of methylated and ethylated phenols and thereafter the complex is decomposed to produce a high purity meta-cresol. It is a feature of the invention that either of the complexing steps may be performed first; that is, either of the anhydrous halide salt or the sodium acetate may be added to the mixture, followed thereafter by addition of the other complexing agent.

REFERENCES:
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Sharpless, et al. "Jour. Organic Chemistry" vol. 40, #9 (1975), Rapid Separation of Organic Complexes by Formation of Metal Complexes.

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