Combined use of angiotensin inhibitors and nitric oxide stimulat

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514310, A61K 900

Patent

active

061398470

ABSTRACT:
This invention pertains to the use of a combination of angiotensin inhibitors and nitric oxide stimulators to slow and reverse the process of fibrosis in the body. This combination of medicaments is particularly useful in the treatment of a variety of cardiovascular fibrotic pathologies, such as that associated with left ventricular hypertrophy secondary to hypertension, myocardial infarction, and myocarditis.

REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5264447 (1993-11-01), Ohtawa
patent: 5268358 (1993-12-01), Fretto
patent: 5278192 (1994-01-01), Fung et al.
patent: 5304541 (1994-04-01), Purchio et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5312621 (1994-05-01), Berman et al.
patent: 5326559 (1994-07-01), Miller
patent: 5358959 (1994-10-01), Halerpin et al.
patent: 5374660 (1994-12-01), Murad et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5382587 (1995-01-01), Baldwin et al.
patent: 5385937 (1995-01-01), Stamler et al.
patent: 5492904 (1996-02-01), Wong
patent: 5512681 (1996-04-01), Boswell et al.
patent: 5536723 (1996-07-01), Loscalzo et al.
patent: 5538991 (1996-07-01), Ashton et al.
patent: 5631284 (1997-05-01), Legzdins et al.
patent: 5641793 (1997-06-01), Bradbury
patent: 5958926 (1999-09-01), Garvey et al.
K. T. Weber et al., "Structural Remodeling in Hypertensive Heart Disease and the Role of Hormones" Hypertension 23:869-877 (1994).
D. C. Crawford et al., "Angiotensin II Induces Fibronectin Expression Associated with Cardiac Fibrosis in the Rat" Circulation Research 74:727-739 (1994).
D. S. Bredt et al., "Nitric Oxide: A Physiologic Messenger Molecule" Annu. Rev. Biochem. 63: 175-95 (1994).
J. Hou et al., "Influence of Nitric Oxide Synthase Inhibition onCardiac Fibrosis Induced by Angiotensin II Infusion",Circulation vol. 90, No. 4, Part 2: I-627, Abstract No. 3374 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Combined use of angiotensin inhibitors and nitric oxide stimulat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combined use of angiotensin inhibitors and nitric oxide stimulat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combined use of angiotensin inhibitors and nitric oxide stimulat will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2048052

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.