Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1997-02-18
2000-10-31
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
514310, A61K 900
Patent
active
061398470
ABSTRACT:
This invention pertains to the use of a combination of angiotensin inhibitors and nitric oxide stimulators to slow and reverse the process of fibrosis in the body. This combination of medicaments is particularly useful in the treatment of a variety of cardiovascular fibrotic pathologies, such as that associated with left ventricular hypertrophy secondary to hypertension, myocardial infarction, and myocarditis.
REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5264447 (1993-11-01), Ohtawa
patent: 5268358 (1993-12-01), Fretto
patent: 5278192 (1994-01-01), Fung et al.
patent: 5304541 (1994-04-01), Purchio et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5312621 (1994-05-01), Berman et al.
patent: 5326559 (1994-07-01), Miller
patent: 5358959 (1994-10-01), Halerpin et al.
patent: 5374660 (1994-12-01), Murad et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5382587 (1995-01-01), Baldwin et al.
patent: 5385937 (1995-01-01), Stamler et al.
patent: 5492904 (1996-02-01), Wong
patent: 5512681 (1996-04-01), Boswell et al.
patent: 5536723 (1996-07-01), Loscalzo et al.
patent: 5538991 (1996-07-01), Ashton et al.
patent: 5631284 (1997-05-01), Legzdins et al.
patent: 5641793 (1997-06-01), Bradbury
patent: 5958926 (1999-09-01), Garvey et al.
K. T. Weber et al., "Structural Remodeling in Hypertensive Heart Disease and the Role of Hormones" Hypertension 23:869-877 (1994).
D. C. Crawford et al., "Angiotensin II Induces Fibronectin Expression Associated with Cardiac Fibrosis in the Rat" Circulation Research 74:727-739 (1994).
D. S. Bredt et al., "Nitric Oxide: A Physiologic Messenger Molecule" Annu. Rev. Biochem. 63: 175-95 (1994).
J. Hou et al., "Influence of Nitric Oxide Synthase Inhibition onCardiac Fibrosis Induced by Angiotensin II Infusion",Circulation vol. 90, No. 4, Part 2: I-627, Abstract No. 3374 (1994).
Brecher Peter
Chobanian Aram
Harrison Robert H.
Trustees of Boston University
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