Peptide compositions for the treatment of HIV

Details Peptide compositions for the treatment of HIV Peptide compositions for the treatment of HIV

1997-10-07

2000-10-31

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241881, 4241841, 4241931, 4241941, 4242071, 42419611, 4242041, 530324, 530325, A61K 3921, A61K 3900, A61K 3938, A61K 39385

Patent

active

061398438

ABSTRACT:
The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp120 principal neutralizing domain (PND) of HIV, gp41, and Nef (p27) of HIV and carriers which enhance immunogenicity. The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide conjugates. Also provided by present invention is a method for reducing the level of HIV titers in a mammal by administering to the mammal a peptide composition of the present invention in an amount effective to reduce the level of HIV titers. The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of antibody in the mucosa, and the production of cytotoxic lymphocytes. The peptide conjugate compositions of the present invention also elicit neutralizing antibodies and decrease viral loads in a subject.

REFERENCES:
patent: 4771127 (1988-09-01), Cryz et al.
patent: 4784941 (1988-11-01), Watanabe et al.
patent: 4879212 (1989-11-01), Wang et al.
patent: 5019387 (1991-05-01), Haynes et al.
Cohen et al: "Jitters Jeopardize AIDS Vaccine Trails", Science, vol. 262, pp. 980-981, 1993.
Lachmann, et al., Ciba Foundation Sym., 119:25-57 (1986).
Matthews, et al., Proc. Natl. Acad. Sci., 83: 9709-9713 (Dec. 1986).
Putney, et al., Science, 234:1392-1395 (Dec. 1986).
Matthews, et al., Haematology and Blood Transfusion, 31:414-422 (1987).
Rusche, et al., Proc. Natl. Acad. Sci., 84:6924-6928 (Oct. 1987).
Parker, et al., Proc. Natl. Acad. Sci., 85:1932-1936 (Mar. 1988).
Rusche, et al., Proc. Natl. Acad. Sci., 85:3198-3202 (May 1988).
Goudsmit, et al., Proc. Natl. Acad. Sci., 85:4478-4482 (Jun. 1988).
Looney, et al., Science, 241:357-359 (Jul. 1988).
Skinner, et al., Journal of Virology, 64:4195-4200 (Nov. 1988).
Goedert, et al., The Lancet, III:1351-1354 (Dec. 1989).
Nara, Vaccines, 09:137-144 (1989).
Javaherian, et al., Proc. Natl. Acad. Sci., 86:6768-6772 (Sep. 1989).
Broliden, et al., AIDS, 3:577-582 (1989).
Meloen, et al., J. Gen Virol., 70:1505-1512 (1989).
Parker, et al., Journal of Immunology, 142:3612-3619 (May 1989).
Rossi, et al., Proc. Natl. Acad. Sci., 86:8055-8058 (Oct. 1989).
LaRosa, et al., Science, 249:932-935 (Dec. 1989).
Nara, et al., Journal of Virology, 64:3779-3791 (Aug. 1990).
Lussow, et al., Proc. Natl. Acad. Sci., 87:2960-2964 (Apr. 1990).
Devash, et al., Proc. Natl. Acad. Sci., 87:3445-3449 (May 1990).
Devash, et al., Aids Research and Human Retroviruses, 6:307-315 (1990).
Neurath, et al., Molecular Immunology, 27:539-549 (1990).
Zwart, et al., The Lancet, 474 (Feb. 1990).
Schild, et al., The Lancet, 335:1081-1084 (May 1990).
Brown, The Washington Post (Jun. 1993).
Cryz, et al., Annals New York Academy of Sciences, 693:194-201 (1993).
Greene, Scientific American, 99-105 (Sep. 1993).
White-Schart, et al., Virology, 192:197-206 (1993).
Rubinstein, et al., Aids Research and Human Retroviruses, 10, Supp. 2 (1994).
Butini, et al., Journal of Cellular Biochemistry, Supp. 18B, 1994, p. 147.
Rubinstein, et al., Eur. J. Pediatr (1995) 154 [Suppl. 3]:S28-S29.
Cryz, Jr. et. al., Vaccine, 13:67-71 (1995).
Rubinstein, et al., AIDS 1995, 9:243-251.
Mann, et al., Scientific American, 81-107 (Jul. 1998).

Affiliated with

Also associated with

Rating

Peptide compositions for the treatment of HIV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide compositions for the treatment of HIV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide compositions for the treatment of HIV will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2048018