Tissue plasminogen activator medicinal composition

Details Tissue plasminogen activator medicinal composition Tissue plasminogen activator medicinal composition

1997-09-05

2000-10-31

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 514 42, 514 43, 435212, A61K 3848, A61K 3170, C12N 948, A01N 4304

Patent

active

061398381

ABSTRACT:
The present invention provides a t-PA medicinal preparation obtained by remarkably improving the solubility and stability of t-PA or modified t-PA. Nicotinamide or a derivative thereof is incorporated into t-PA or modified t-PA-containing solvent system. If necessary, a citrate buffer solution is also used. The t-PA-containing medicinal composition is in the form of, for example, a freeze-dried preparation.

REFERENCES:
patent: 4898826 (1990-02-01), Duffy et al.
patent: 4929444 (1990-05-01), Johnston et al.
patent: 4935237 (1990-06-01), Higgins et al.
patent: 4968617 (1990-11-01), Johnston et al.
patent: 5037646 (1991-08-01), Higgins et al.
patent: 5112609 (1992-05-01), Johnston et al.
patent: 5589361 (1996-12-01), Hotchkiss et al.
Harris, T.J.R. Protein Engineering1(6):449-458 (1987).
Database WPI, Derwent Publications, AN 79-53236B, JP 54-070419, Jun. 6, 1. 9
Database WPI, Derwent Publications, AN 93-278215, JP 5-194265, Aug. 3, 1993.
Yoshimasa Saito, et al., Biotechnology Progress, vol. 10, No. 5, pp. 472-479, "Production and Characterization of a Novel Tissue-Type Plasminogen Activator Derivative in Escherichia Coli", 1994.
Pharmacopeial Previews, pp. 1222-1230, "Monographs", Nov.-Dec. 1990.
J. Truelove, et al., International Journal of Pharmaceutics, vol. 19, pp. 17-25, "Solubility Enhancement of Some Developmental Anti-Cancer Nucleoside Analogs by Complexation with Nicotinamide", 1984.
Richard A. Kenley, et al., Journal of Pharmaceutical Sciences, vol. 75, No. 7, pp. 648-653, "Water Soluble Complexes of the Antiviral Drugs, 9-[(1,3-Dihydroxy-2-Proproxy)Methyl]Guanine and Acyclovir: The Role of Hydrophobicity in Complex Formation", Jul. 1986.
Alaa Abdul Rasool, et al., Journal of Pharmaceutical Sciences, vol. 80, No. 4, pp. 387-393, "Solubility Enhancement of Some Water-Soluble Drugs in the Presence of Nicotinamide and Related Compounds", Apr. 1991.

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