Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1980-02-08
1981-05-12
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548338, C07D23394, C07D23393
Patent
active
042673496
ABSTRACT:
Novel 2-substituted 1-alkyl-nitroimidazoles and a process for their preparation by reaction of 2-methyl-nitroimidazoles with oxalic acid diesters, followed by reaction of the resulting nitroimidazol-2-yl-pyruvic acid esters with chlorine, in turn followed, if desired, by reaction of the resulting 2-dihalomethyl-nitroimidazoles with water.
Both the novel and the known compounds obtainable by the process of the invention are valuable starting materials for the preparation of dyes, pesticides and drugs.
REFERENCES:
Albright, J., et al., J. Het. Chem., 10, 899-907 (1973).
Theilheimer, W., Synthetic Methods of Organic Chemistry, Interscience, New York, vol. 6 (1952), p. 214; vol. 12 (1958), p. 138; vol. 17 (1963), p. 94; vol. 24 (1970), p. 386.
Simchen, G., et al., Liebigs Ann. Chem. 1974, p. 1807 (No. 11).
Chemical Abstracts, 79:115436v (1973) [German OLS No. 2,203,542, 8/16/73, Hrstka et al.].
March, J., Advanced Organic Chemistry, McGraw-Hill, New York, 1968, pp. 458-459.
Wideqvist, S., J. Am. Chem. Soc., 71, 4152 (1949).
Hagen Helmut
Kohler Rolf-Dieter
BASF - Aktiengesellschaft
Schwartz Richard A.
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