Compositions, including pharmaceutical compositions, for inhibit

Details Compositions, including pharmaceutical compositions, for inhibit Compositions, including pharmaceutical compositions, for inhibit

1997-01-16

1998-12-22

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142378, 5142385, 514331, 514399, 514561, 514631, 540605, 544164, 546223, 564230, 564240, 564227, A61K 31535, A61K 31155, A61K 3115, A61K 31415, A61K 31495, C07C13310

Patent

active

058520090

ABSTRACT:
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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